Application of solid-state NMR in characterization of bone related tissue engineering.

Solid-state NMR has the potential to contribute to the quality of monitoring of the in growth of synthetic biomaterials in bone related tissue engineering. Severe experimental difficulties arise from the morphological diversity of bone, from the coexistence, interrelationship and great complexity of its organic and inorganic components, and lastly, from the substantial sensitivity of bone samples to physical and chemical effects. High-resolution solid-state NMR gives us the opportunity to look specifically at selected magnetic nuclei in whole bone without any chemical pretreatment, thus avoiding interference with bone structure. Solid-state NMR spectroscopy is thus an excellent tool to obtain such high-resolution information on bone samples not subjected to any chemical pretreatment. This short review has thus discussed current application of solid-state NMR in characterization of bone related tissue engineering.